DEOXYVACISINONE HCl

• CAT Number: T000016
• CAS Number: 2446-62-0 (parent)
• Molecular Formula: C12H12N2O.HCl
• Purity: ≥95%
• Synonyms: 6,7,8,9-Tetrahydro-11H-pyrido[2,1-b]quinazolin-11-one hydrochloride
• Solubility: In ethanol and waterNot well in chloroform and acetone
• Storage: Stable in freeze-dried stateStore at +4°C, in dark place.

DEOXYVACISINONE HCl inhibits cholinesterase activity in vitro.

In vivo, high doses induce sleep and enhance the effect of soporifics.

Quinazolone alkaloid<!–C12H12N2O.HCl–>, synthetic.

High dose inhibits orientation reaction and motor functions. So, it induces somnolence, even sleep.

Half and quarter LD₅₀ doses (= moderate doses) enhance the effect of soporifics. In vitro, it causes weak inhibition of cholinesterase acitivity with IC₅₀ = 6.2×10^-4 g/ml, and of monoaminoxidase at 10^-4 M reduces by 18.8 % its activity.

Reference

– Fitzgerald et al., /6, 7, 8, 9-tetrahydropyrido-quinazoline, a new class of alkaloids from Mackinlava species (Araliaceae)/ Aust. J. Chem. (1966). 19(1):151-159

– Spath et al., /Uber Derivate des Peganins und ihre Ring-Homologen/ J. Mitt. Uber Peganin, Chem. Ber. 6 (1935). 68:2221-2226

– Jen et al., /A new class of antihypertensive agents, 1, 2, 3, 5-Tetrahydroimidazo [2,1-b] quinazoline./ J. Med. Chem.1 (1972). 15(7):727-731

– Touliaganov, Ph. D. Thesis, Moscow (1981) (Russian).