Dermorphin

• CAT Number: I013425
• CAS Number: 77614-16-5
• Molecular Formula: C40H50N8O10
• Molecular Weight: 802.87
• Purity: ≥95%
• Synonyms: (2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C40H50N8O10/c1-23(44-37(55)29(41)18-25-9-13-27(50)14-10-25)36(54)46-30(19-24-6-3-2-4-7-24)38(56)43-21-34(52)45-31(20-26-11-15-28(51)16-12-26)40(58)48-17-5-8-33(48)39(57)47-32(22-49)35(42)53/h2-4,6-7,9-16,23,29-33,49-51H,5,8,17-22,41H2,1H3,(H2,42,53)(H,43,56)(H,44,55)(H,45,52)(H,46,54)(H,47,57)/t23-,29+,30+,31+,32+,33+/m1/s1
• InChIKey: FHZPGIUBXYVUOY-VWGYHWLBSA-N
• SMILES: C[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N)NC(=O)[C@H](CC4=CC=C(C=C4)O)N

Dermorphin(CAT: I013425) is a naturally occurring heptapeptide that belongs to the class of opioid peptides, originally isolated from the skin of certain South American frogs. It is known for its potent analgesic (pain-relieving) properties, with an affinity for the μ-opioid receptor, making it significantly more potent than morphine. Dermorphin’s unique structure, featuring a D-alanine residue at its second position, contributes to its high receptor selectivity and reduced side effects compared to other opioids. Due to its powerful analgesic effects, Dermorphin is of interest in pain management research and has potential therapeutic applications. However, its use is primarily confined to research settings due to its potency and the risk of adverse effects.