derquantel

• CAT Number: M037801
• CAS Number: 187865-22-1
• Molecular Formula: C28H37N3O4
• Molecular Weight: 479.62
• Purity: ≥95%
• Synonyms: (1’R,5’aS,7’R,8’aS,9’aR)-2′,3′,8’a,9,9′,10-hexahydro-1′-hydroxy-1′,4,4,8′,8′,11′-hexamethyl-spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7′(8’H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizin]-10′-one
• Target: Nicotinic Receptor
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: (1S,6R,7R,9S,11R)-6-hydroxy-4',4',6,10,10,13-hexamethylspiro[3,13-diazatetracyclo[5.5.2.01,9.03,7]tetradecane-11,8'-9,10-dihydro-[1,4]dioxepino[2,3-g]indole]-14-one
• InChI: InChI=1S/C28H37N3O4/c1-23(2)10-12-34-21-18(35-23)8-7-17-20(21)29-15-26(17)14-27-16-31-11-9-25(5,33)28(31,22(32)30(27)6)13-19(27)24(26,3)4/h7-8,10,12,19,29,33H,9,11,13-16H2,1-6H3/t19-,25+,26-,27+,28-/m0/s1
• InChIKey: DYVLXWPZFQQUIU-WGNDVSEMSA-N
• SMILES: C[C@]1(CCN2[C@]13C[C@@H]4[C@](C2)(C[C@]5(C4(C)C)CNC6=C5C=CC7=C6OC=CC(O7)(C)C)N(C3=O)C)O

Derquantel（Cat No.:M037801）is a selective and potent antagonist of nicotinic acetylcholine receptors (nAChRs) in nematodes, used primarily as an anthelmintic in veterinary medicine. It is effective against a wide range of gastrointestinal and lung parasites in livestock, including sheep and cattle. By inhibiting the binding of acetylcholine to nematode receptors, Derquantel disrupts muscle function, leading to paralysis and eventual expulsion of the parasites. It is often combined with abamectin to enhance efficacy and provide broader-spectrum parasite control. Its use is crucial for maintaining livestock health and productivity.

Reference

Ligands of the nicotinic acetylcholine receptor as insecticides. Nauen R. et al. Pestic. Sci. 1999, 55, 608-610.Semisynthesis of 2-deoxo- and 3-epi-paraherquamide A. Lee B.H. et al. Bioorg. Med. Chem. Lett. 2001, 11, 553-554.Marcfortine and paraherquamide class of anthelmintics: Discovery of PNU-141962. Lee B.H. et al. Current Topics in Med. Chem. 2002, 2, 779.