Des-(R)-piperidin-3-amine 8-(R)-(Piperidin-3-ylamino) Linagliptin

• CAT Number: R029712
• CAS Number: 1446263-38-2
• Molecular Formula: C25H28N8O2
• Molecular Weight: 472.553
• Purity: ≥95%
• Synonyms: 7-(2-Butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-8-[(3R)-3-piperidinylamino]-1H-purine-2,6-dione; (R)-7-(But-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-8-(piperidin-3-ylamino)-1H-purine-2,6(3H,7H)-dione
• Storage: -20°C
• IUPAC Name: 7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-8-[[(3R)-piperidin-3-yl]amino]purine-2,6-dione
• InChI: InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(30-24(32)28-17-9-8-12-26-14-17)31(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)29-20/h6-7,10-11,17,26H,8-9,12-15H2,1-3H3,(H,28,30)/t17-/m1/s1
• InChIKey: DOQKYHYFAIBWOA-QGZVFWFLSA-N
• SMILES: CC#CCN1C2=C(N=C1NC3CCCNC3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C

Des-(R)-piperidin-3-amine 8-(R)-(Piperidin-3-ylamino) linagliptin is a derivative of linagliptin, a medication used to treat type 2 diabetes. It functions as a dipeptidyl peptidase-4 (DPP-4) inhibitor, enhancing insulin secretion and regulating blood glucose levels. This modified compound is studied for improved pharmacokinetic properties and potential increased efficacy in managing diabetes and related metabolic disorders.