Desbutyl Dronedarone Hydrochloride

• CAT Number: R051541
• CAS Number: 197431-02-0
• Molecular Formula: C27H37ClN2O5S
• Molecular Weight: 537.112
• Purity: ≥95%
• Synonyms: N-[2-Butyl-3-[4-[3-(butylamino)propoxy]benzoyl]-5-benzofuranyl]-methanesulfonamide Hydrochloride; SR 35021; Dronedarone Impurity D
• Target: Thyroid Hormone Receptor
• Storage: Desiccate at +4 ℃
• IUPAC Name: N-[2-butyl-3-[4-[3-(butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide;hydrochloride
• InChI: InChI=1S/C27H36N2O5S.ClH/c1-4-6-9-25-26(23-19-21(29-35(3,31)32)12-15-24(23)34-25)27(30)20-10-13-22(14-11-20)33-18-8-17-28-16-7-5-2;/h10-15,19,28-29H,4-9,16-18H2,1-3H3;1H
• InChIKey: ZDXBTJLIQYUYSZ-UHFFFAOYSA-N
• SMILES: CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCNCCCC.Cl

Desbutyl dronedarone hydrochloride is a metabolite of dronedarone, an antiarrhythmic medication used to treat atrial fibrillation. This compound is formed in the liver through the demethylation of dronedarone. Desbutyl dronedarone retains some antiarrhythmic activity but is less potent than its parent compound. Research on this metabolite focuses on its pharmacokinetics, pharmacodynamics, and potential contributions to therapeutic effects and adverse reactions associated with dronedarone treatment. Understanding its role aids in optimizing dronedarone therapy for cardiovascular conditions.