Descladinose 6-N-Desmethyl Azithromycin

• CAT Number: C000393
• CAS Number: 111247-94-0
• Molecular Formula: C₂₉H₅₆N₂O₉
• Molecular Weight: 576.76
• Purity: ≥95%
• Synonyms: (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10,13-tetrahydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one; CP 60300
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Storage: -20°C, Hygroscopic
• IUPAC Name: (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10,13-tetrahydroxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
• InChI: InChI=1S/C29H56N2O9/c1-11-21-29(8,37)24(34)19(6)30-14-15(2)13-28(7,36)25(17(4)22(32)18(5)26(35)39-21)40-27-23(33)20(31(9)10)12-16(3)38-27/h15-25,27,30,32-34,36-37H,11-14H2,1-10H3/t15-,16-,17+,18-,19-,20+,21-,22+,23-,24-,25-,27+,28-,29-/m1/s1
• InChIKey: LOMZTTMTKSVHAG-NHUOXGILSA-N
• SMILES: CCC1C(C(C(NCC(CC(C(C(C(C(C(=O)O1)C)O)C)OC2C(C(CC(O2)C)N(C)C)O)(C)O)C)C)O)(C)O

Descladinose 6-N-Desmethyl Azithromycin（Cat No.:C000393）is a specialized derivative of the macrolide antibiotic azithromycin, used primarily in pharmaceutical research. This compound, characterized by the removal of the cladinose sugar and the N-methyl group, is valuable for studying the structure-activity relationships and metabolic pathways of azithromycin analogs. It plays a critical role in the development of novel antibiotics and the investigation of bacterial resistance mechanisms. Descladinose 6-N-Desmethyl Azithromycin supports the advancement of medicinal chemistry and drug discovery efforts aimed at combating resistant bacterial strains.

Reference

Hunter, R., et al.: J. Vet. Pharmacol. Ther., 26, 117 (2003);