For research use only. Not for therapeutic Use.
Desethyl Chloroquine Diphosphate（Cat No.:I016827）is a primary active metabolite of chloroquine, an antimalarial drug used to treat and prevent Plasmodium infections. It works by interfering with the parasite’s ability to detoxify heme, leading to its death. This metabolite contributes significantly to the pharmacological activity and extended half-life of chloroquine. Beyond its antimalarial effects, it has been studied for potential applications in autoimmune diseases and viral infections due to its immunomodulatory properties. Desethyl Chloroquine Diphosphate remains a focus of research in pharmacokinetics and drug resistance mechanisms.
| Catalog Number | I016827 |
| CAS Number | 247912-76-1 |
| Molecular Formula | C₁₆H₂₈ClN₃O₈P₂ |
| Purity | ≥95% |
| Storage | 4°C, protect from light, stored under nitrogen |
| IUPAC Name | 4-N-(7-chloroquinolin-4-yl)-1-N-ethylpentane-1,4-diamine;phosphoric acid |
| InChI | InChI=1S/C16H22ClN3.2H3O4P/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16;2*1-5(2,3)4/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20);2*(H3,1,2,3,4) |
| InChIKey | PIKNKEKUPZTKFZ-UHFFFAOYSA-N |
| SMILES | CCNCCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O |
| Reference | [1]. Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100.<br>[2]. Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74.<br>[3]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43. |
