Desethyl Chloroquine

• CAT Number: R006709
• CAS Number: 1476-52-4
• Molecular Formula: C16H22ClN3
• Molecular Weight: 291.823
• Purity: ≥95%
• Synonyms: Chloroquine Related Compound D; 7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline; Monodesethylchloroqu​ine
• Storage: -20°C
• IUPAC Name: 4-N-(7-chloroquinolin-4-yl)-1-N-ethylpentane-1,4-diamine
• InChI: InChI=1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)
• InChIKey: MCYUUUTUAAGOOT-UHFFFAOYSA-N
• SMILES: CCNCCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl

Desethyl Chloroquine(Chloroquine Related Compound D, cas 1476-52-4) is desethyl metabolite of Chloroquine; 

Reference

1: Ajayi FO, Salako LA, Kuye JO. Comparison of the partitioning in vitro of
chloroquine and its desethyl metabolites between the erythrocytes and plasma of
healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989
Jun;18(2):95-100. PubMed PMID: 2547293.

2: Lindström B, Ericsson O, Alván G, Rombo L, Ekman L, Rais M, Sjöqvist F.
Determination of chloroquine and its desethyl metabolite in whole blood: an
application for samples collected in capillary tubes and dried on filter paper.
Ther Drug Monit. 1985;7(2):207-10. PubMed PMID: 4024215.

3: Bergqvist Y, Domeij-Nyberg B. Distribution of chloroquine and its metabolite
desethyl-chloroquine in human blood cells and its implication for the
quantitative determination of these compounds in serum and plasma. J Chromatogr.
1983 Jan 14;272(1):137-48. PubMed PMID: 6841533.

4: Alván G, Ekman L, Lindström B. Determination of chloroquine and its desethyl
metabolite in plasma, red blood cells and urine by liquid chromatography. J
Chromatogr. 1982 Apr 16;229(1):241-7. PubMed PMID: 7085832.

5: Bergqvist Y, Eckerbom S. Simultaneous determination of chloroquine and its
desethyl metabolite in human plasma by gas chromatography. J Chromatogr. 1981 Nov
13;226(1):91-7. PubMed PMID: 7320158.

6: Bergqvist Y, Frisk-Holmberg M. Sensitive method for the determination of
chloroquine and its metabolite desethyl-chloroquine in human plasma and urine by
high-performance liquid chromatography. J Chromatogr. 1980 Nov 14;221(1):119-27.
PubMed PMID: 7451613.