Desethyl Chloroquine

• CAT Number: R006709
• CAS Number: 1476-52-4
• Molecular Formula: C16H22ClN3
• Molecular Weight: 291.82
• Purity: ≥95%
• Synonyms: Chloroquine Related Compound D; 7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline; Monodesethylchloroqu​ine
• Target: Immunology/Inflammation
• Storage: -20°C
• IUPAC Name: 4-N-(7-chloroquinolin-4-yl)-1-N-ethylpentane-1,4-diamine
• InChI: InChI=1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)
• InChIKey: MCYUUUTUAAGOOT-UHFFFAOYSA-N
• SMILES: CCNCCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl

Desethyl Chloroquine（Cat No.:R006709）is a primary metabolite of chloroquine, a well-known antimalarial drug. Formed through hepatic metabolism, it retains antimalarial activity by inhibiting heme detoxification in Plasmodium parasites, leading to toxic heme accumulation and parasite death. Desethyl chloroquine is also studied for its pharmacokinetic properties, including its role in drug efficacy and potential resistance mechanisms. Beyond malaria, it has been explored for immunomodulatory effects and applications in autoimmune diseases. Its significance lies in both its therapeutic activity and its contribution to understanding chloroquine’s pharmacological profile.

Reference

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chloroquine and its desethyl metabolites between the erythrocytes and plasma of
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2: Lindström B, Ericsson O, Alván G, Rombo L, Ekman L, Rais M, Sjöqvist F.
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5: Bergqvist Y, Eckerbom S. Simultaneous determination of chloroquine and its
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