Desethyl Sacubitril-d4

• CAT Number: R036705
• CAS Number: NA
• Molecular Formula: C₂₂H₂₁D₄NO₅
• Molecular Weight: 387.46
• Purity: ≥95%
• Synonyms: (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl[1,1’-biphenyl]-4-pentanoic Acid-d4; (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic Acid-d4; (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentan
• Storage: Store at -20°C
• IUPAC Name: (2R,4S)-4-[(3-carboxy-2,2,3,3-tetradeuteriopropanoyl)amino]-2-methyl-5-(4-phenylphenyl)pentanoic acid
• InChI: InChI=1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19+/m1/s1/i11D2,12D2
• InChIKey: DOBNVUFHFMVMDB-VESNEZPCSA-N
• SMILES: [2H]C([2H])(C(=O)N[C@H](CC1=CC=C(C=C1)C2=CC=CC=C2)C[C@@H](C)C(=O)O)C([2H])([2H])C(=O)O

Desethyl Sacubitril-d4 is a deuterated form of desethyl sacubitril, where four hydrogen atoms are replaced with deuterium. Desethyl sacubitril is an active metabolite of sacubitril, a component of the combination drug sacubitril/valsartan, which is used to treat heart failure. This isotopically labeled compound is employed in pharmaceutical research to study the metabolism, pharmacokinetics, and pharmacodynamics of sacubitril. The deuterium labeling allows for precise tracking and enhanced accuracy in analytical techniques such as mass spectrometry, enabling detailed investigations into the drug’s metabolic pathways, efficacy, and safety profile. Desethyl Sacubitril-d4 is crucial for researchers aiming to optimize heart failure therapies, study drug interactions, and better understand the mechanisms of action and metabolism of sacubitril in clinical settings.