For research use only. Not for therapeutic Use.
Desglymidodrine (ST 1059), the active metabolite of Midodrine (HY-12749), is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure[1][2].
Desglymidodrine (ST 1059) (1-1000 μM) affects vein contraction with the pD2 values (negative logarithm of the concentration which causes 50% of the maximum possible effect) of 4.64 (-log mol/L) in dog isolated femoral veins and 4.48 (-log mol/L) in isolated human saphenous veins, respectively[1].
Desglymidodrine (ST 1059) acts on α1A, α1B, α1D in rat and α2A in human adrenoceptor with the pKi values of 5.89, 5.16, 5.78 and 5.83, respectively[2].
| Catalog Number | R001800 |
| CAS Number | 3600-87-1 |
| Synonyms | 2-amino-1-(2,5-dimethoxyphenyl)ethanol |
| Molecular Formula | C10H15NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3 |
| InChIKey | VFRCNXKYZVQYLX-UHFFFAOYSA-N |
| SMILES | COC1=CC(=C(C=C1)OC)C(CN)O |
| Reference | [1]. K Nakayama, et al. Effects of anisotropine methylbromide (Valpin) and its mixture with sulpyrine on vocalization response and spasm of intestine induced by acetylcholine in dogs. Jpn J Pharmacol. 1972 Apr;22(2):215-20. [2]. Steven ABuckner, et al. ABT-866, a novel α1A-adrenoceptor agonist with antagonist properties at the α1B- and α1D-adrenoceptor subtypes,European Journal of Pharmacology,Volume 449, Issues 1–2,2002,Pages 159-1 |
