For research use only. Not for therapeutic Use.
Desloratadine (CAS 100643-71-8) is a tricyclic H1-antihistamine that is used to treat allergies. It is an active metabolite of loratadine. Desloratadine is a selective H1-antihistamine which functions as an inverse agonist at the histamine H1 receptor; it is also an antagonist at all subtypes of the muscarinic acetylcholine receptors. It has a long-lasting effect and in moderate and low doses. It exhibits only peripheral activity since it does not readily cross the blood-brain barrier; hence, it does not cause drowsiness because it does not readily enter the central nervous system.
| Catalog Number | A000328 |
| CAS Number | 100643-71-8 |
| Synonyms | CH-34117, NSC 675447 |
| Molecular Formula | C19H19ClN2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | -20°C |
| Overview of Clinical Research | <span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">Desloratadine is a <span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Histamine H1 receptor antagonist. It has been granted for the new molecular entity.</span></span></span></span> |
| IUPAC Name | 13-chloro-2-piperidin-4-ylidene-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene |
| InChI | InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2 |
| InChIKey | JAUOIFJMECXRGI-UHFFFAOYSA-N |
| SMILES | C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4 |
| Reference | 1: Ainurofiq A, Mauludin R, Mudhakir D, Umeda D, Soewandhi SN, Putra OD, Yonemochi E. Improving mechanical properties of desloratadine via multicomponent crystal formation. Eur J Pharm Sci. 2017 Sep 27;111:65-72. doi: 10.1016/j.ejps.2017.09.035. [Epub ahead of print] PubMed PMID: 28958892.<br /> |
