Desmethyl Sibutramine

• CAT Number: R045016
• CAS Number: 168835-59-4
• Molecular Formula: C16H24ClN
• Molecular Weight: 265.825
• Purity: ≥95%
• Synonyms: 1-[1-(4-chlorophenyl)cyclobutyl]-N,3-dimethylbutan-1-amine; N-Desmethylsibutramine.
• Storage: Desiccate at RT
• IUPAC Name: 1-[1-(4-chlorophenyl)cyclobutyl]-N,3-dimethylbutan-1-amine
• InChI: InChI=1S/C16H24ClN/c1-12(2)11-15(18-3)16(9-4-10-16)13-5-7-14(17)8-6-13/h5-8,12,15,18H,4,9-11H2,1-3H3
• InChIKey: PLXKZKLXYHLWHR-UHFFFAOYSA-N
• SMILES: CC(C)CC(C1(CCC1)C2=CC=C(C=C2)Cl)NC

Desmethyl sibutramine is a metabolite of sibutramine, a drug formerly used for weight loss. It functions by inhibiting the reuptake of serotonin, norepinephrine, and dopamine, enhancing satiety and energy expenditure. Due to its stimulant properties, desmethyl sibutramine is scrutinized for its cardiovascular effects, contributing to the regulatory withdrawal of sibutramine from the market due to safety concerns.

Overview of Clinical Research

Mechanism of Action: Adrenergic receptor antagonists; Dopamine uptake inhibitors; Serotonin uptake inhibitors
Orphan Drug Status: No