Desmethyl Tenofovir Disoproxil-d4 Fumarate

• CAT Number: R059737
• CAS Number: NA
• Molecular Formula: C₂₂H₂₈D₄N₅O₁₄P
• Molecular Weight: 625.51
• Purity: ≥95%
• Synonyms: 5-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]-2,4,6,8-Tetraoxa-5-phosphanonanedioic Acid Bis(1-methylethyl) Ester 5-Oxide-d4 (2E)-2-Butenedioate
• Storage: Store at +4C
• IUPAC Name: [[2-(6-aminopurin-9-yl)-1,1,2,2-tetradeuterioethoxy]methyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate;but-2-enedioic acid
• InChI: InChI=1S/C18H28N5O10P.C4H4O4/c1-12(2)32-17(24)28-9-30-34(26,31-10-29-18(25)33-13(3)4)11-27-6-5-23-8-22-14-15(19)20-7-21-16(14)23;5-3(6)1-2-4(7)8/h7-8,12-13H,5-6,9-11H2,1-4H3,(H2,19,20,21);1-2H,(H,5,6)(H,7,8)/i5D2,6D2
• InChIKey: ROFRIUDSSWUIQC-NXMSQKFDSA-N
• SMILES: [2H]C([2H])(C([2H])([2H])OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)N1C=NC2=C(N=CN=C21)N.C(=CC(=O)O)C(=O)O

Desmethyl Tenofovir Disoproxil-d4 Fumarate is a deuterated analog of Desmethyl Tenofovir Disoproxil, with four deuterium atoms incorporated into its structure. This isotopically labeled compound is vital for research in antiviral drug development, particularly in studying the pharmacokinetics and metabolism of nucleotide analogs. The fumarate salt form enhances its stability and solubility, making it ideal for precise analytical studies, including mass spectrometry and NMR spectroscopy. Desmethyl Tenofovir Disoproxil-d4 Fumarate is used in tracing studies to explore drug absorption, distribution, metabolism, and excretion (ADME) pathways, providing critical insights for optimizing antiviral therapies