Desmetramadol

• CAT Number: I014325
• CAS Number: 80456-81-1 (free base)
• Molecular Formula: C15H23NO2
• Molecular Weight: 249.35
• Purity: ≥95%
• Synonyms: Desmetramadol; O-desmethyl tramadol; O desmethyl tramadol; Mono-O-demethyltramadol; Mono O demethyltramadol; Tramadol M1 metabolite;;3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol
• Solubility: Soluble in DMSO
• IUPAC Name: 3-[2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]phenol
• InChI: InChI=1S/C15H23NO2/c1-16(2)11-13-6-3-4-9-15(13,18)12-7-5-8-14(17)10-12/h5,7-8,10,13,17-18H,3-4,6,9,11H2,1-2H3/t13-,15+/m1/s1
• InChIKey: UWJUQVWARXYRCG-HIFRSBDPSA-N
• SMILES: OC1=CC=CC([C@]2(O)[C@@H](CN(C)C)CCCC2)=C1

Desmetramadol(CAT: I014325) is an active metabolite of the opioid analgesic tramadol, known for its analgesic (pain-relieving) properties. It results from the biotransformation of tramadol in the body, specifically through O-demethylation. Desmetramadol exerts its effects primarily by binding to the μ-opioid receptor, contributing to the overall analgesic effect of tramadol. Additionally, it plays a role in inhibiting the reuptake of serotonin and norepinephrine, further enhancing its pain-relieving properties. While Desmetramadol is effective in pain management, its potency and activity are significant factors in the pharmacological profile of tramadol, and it contributes to the potential for opioid-related side effects, including dependency and tolerance. Due to these properties, it is studied in the context of pain management and opioid pharmacology.