Des(sulfonylethyl)amino Hydroxy Lapatinib

• CAT Number: C000143
• CAS Number: 320337-48-2
• Molecular Formula: C₂₆H₁₉ClFN₃O₃
• Molecular Weight: 475.9
• Purity: ≥95%
• Synonyms: 5-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-furanmethanol
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
• Appearance: Pale Yellow to Light Yellow Solid
• Storage: -20°C, Inert atmosphere

Des(sulfonylethyl)amino Hydroxy Lapatinib(CAT: C000143) holds significance in the realm of pharmaceutical chemistry, particularly in the context of cancer treatment. It is related to Lapatinib, a selective inhibitor of epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases. Lapatinib is utilized to treat breast cancer, particularly metastatic breast cancer that has progressed after trastuzumab treatment and other chemotherapy options.

Reference

Konecny, G., et al.: Cancer Res., 66, 1630 (2006); Geyer, C., et al.: N. Engl. J. Med., 355, 2733 (2006);