Destruxin A

For research use only. Not for therapeutic Use.

  • CAT Number: R000167
  • CAS Number: 6686-70-0
  • Molecular Formula: C29H47N5O7
  • Molecular Weight: 577.71
  • Purity: ≥95%
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Destruxin A (DA) is a cyclo-peptidic mycotoxin from the entomopathogenic fungus Metarhizium anisopliae, with insecticidal, anti-viral and antiproliferative activities[1].


Catalog Number R000167
CAS Number 6686-70-0
Synonyms

(3R,10S,13S,16S,19S)-16-[(2S)-butan-2-yl]-10,11,14-trimethyl-13-propan-2-yl-3-prop-2-enyl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone

Molecular Formula C29H47N5O7
Purity ≥95%
InChI InChI=1S/C29H47N5O7/c1-9-12-21-27(38)34-16-11-13-20(34)26(37)31-23(18(5)10-2)28(39)33(8)24(17(3)4)29(40)32(7)19(6)25(36)30-15-14-22(35)41-21/h9,17-21,23-24H,1,10-16H2,2-8H3,(H,30,36)(H,31,37)/t18-,19-,20-,21+,23-,24-/m0/s1
InChIKey XIYSEKITPHTMJT-OCCJOITDSA-N
SMILES CCC(C)C1C(=O)N(C(C(=O)N(C(C(=O)NCCC(=O)OC(C(=O)N2CCCC2C(=O)N1)CC=C)C)C)C(C)C)C
Reference

[1]. Gong L, et al. Gene expression profile of Bombyx mori hemocyte under the stress of destruxin A. PLoS One. 2014 May 6;9(5):e96170.
 [Content Brief]

[2]. Pal S, et al. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. J Biol Chem. 2007 Mar 23;282(12):8969-77.
 [Content Brief]

[3]. Odier F, et al. In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E. Biol Cell. 1992;74(3):267-71.
 [Content Brief]

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