DETA NONOate

For research use only. Not for therapeutic Use.

  • CAT Number: M099683
  • CAS Number: 146724-94-9
  • Molecular Formula: C4H13N5O2
  • Molecular Weight: 163.18
  • Purity: ≥95%
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DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting[1][2].
DETA NONOate (100 μM; 16 h) induces growth in an Mycobacterium abscessus complex (MABC) R morphotype by reduced glycopeptidolipid (GPL) expression of M. abscessus subspecies abscessus (Mab)[3].
DETA NONOate (15-150 μg/rat, i.c.v., once) exhibits a nociceptive effect in the rat formalin model[2].
DETA NONOate (1 µM) reduces ischemia- or ischemia/reperfusion-induced injury to cardiac mitochondria and prevents apoptotic cell death[4].


Catalog Number M099683
CAS Number 146724-94-9
Synonyms

(Z)-[bis(2-aminoethyl)amino]-hydroxyimino-oxidoazanium

Molecular Formula C4H13N5O2
Purity ≥95%
InChI InChI=1S/C4H13N5O2/c5-1-3-8(4-2-6)9(11)7-10/h10H,1-6H2/b9-7-
InChIKey YNRCBOXEDICOIX-CLFYSBASSA-N
SMILES C(CN(CCN)[N+](=NO)[O-])N
Reference

[1]. Soichiro Sonoda, et al. Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells. Sci Rep. 2018 Feb 21;8(1):3419.
 [Content Brief]

[2]. S Shibuta, et al. A new nitric oxide donor, NOC-18, exhibits a nociceptive effect in the rat formalin model. EJ Neurol Sci. 1996 Sep 15;141(1-2):1-5
 [Content Brief]

[3]. Nandanwar N, et al. Growth medium and nitric oxide alter Mycobacterium abscessus morphotype and virulence. Microbiol Res. 2021 Dec;253:126887.
 [Content Brief]

[4]. Umbrasas D, et al. Nitric Oxide Donor NOC-18-Induced Changes of Mitochondrial Phosphoproteome in Rat Cardiac Ischemia Model. Medicina (Kaunas). 2019 Sep 24;55(10):631.
 [Content Brief]

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