Dexamethasone 11,21-diacetate

• CAT Number: C000776
• CAS Number: 3949-26-6
• Molecular Formula: C₂₆H₃₃FO₇
• Molecular Weight: 476.53
• Purity: ≥95%
• Synonyms: (11β,16α)-1,21-bis(acetyloxy)-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• Appearance: Light Brown Solid
• Storage: -20°C, Hygroscopic
• IUPAC Name: [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-11-acetyloxy-9-fluoro-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
• InChI: InChI=1S/C26H33FO7/c1-14-10-20-19-7-6-17-11-18(30)8-9-23(17,4)25(19,27)22(34-16(3)29)12-24(20,5)26(14,32)21(31)13-33-15(2)28/h8-9,11,14,19-20,22,32H,6-7,10,12-13H2,1-5H3/t14-,19+,20+,22+,23+,24+,25+,26+/m1/s1
• InChIKey: GTECTIGXIMGLJQ-YIEQOVFOSA-N
• SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)OC(=O)C)F)C

Dexamethasone 11,21-diacetate (Cat No.:C000776) is a synthetic corticosteroid derivative of dexamethasone, a potent anti-inflammatory and immunosuppressive medication. The compound features acetyl groups at positions 11 and 21, potentially affecting its pharmacological properties. Researchers likely explore its interactions with glucocorticoid receptors, its metabolism, and therapeutic applications. Investigations into its anti-inflammatory effects, immunomodulatory activities, and potential for various medical conditions could contribute to the development of targeted treatments.

Reference

Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995); Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999); Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999);