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1177-87-3-Dexamethasone acetate Dexamethasone acetate

Dexamethasone acetate

For research use only. Not for therapeutic Use.

  • CAT Number: I000634
  • CAS Number: 1177-87-3
  • Molecular Formula: C24H31FO6
  • Molecular Weight: 434.5
  • Purity: ≥95%
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Related products: Terpinyl Acetate     Demethyleneberberine     Efetaal    

Dexamethasone acetate (Cat.No:I000634) is a synthetic corticosteroid used for its potent anti-inflammatory and immunosuppressive properties. It is commonly prescribed to manage various conditions, including allergies, asthma, autoimmune disorders, and certain types of cancer. Dexamethasone acetate helps reduce inflammation and suppresses the immune system. 


Catalog Number I000634
CAS Number 1177-87-3
Synonyms

[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

Molecular Formula C24H31FO6
Purity ≥95%
Target Glucocorticoid Receptor
Solubility DMSO: ≥ 29 mg/mL
Storage 3 years -20℃ powder
Overview of Clinical Research

<span style=”color:#000000;”><span style=”font-size:12px;”><span style=”caret-color: rgb(0, 0, 0); font-family: arial, helvetica, sans-serif;”>Dexamethasone&nbsp;</span><span style=”font-family: arial, helvetica, sans-serif; caret-color: rgb(33, 33, 33); orphans: 2; widows: 2;”>acetate is a&nbsp;</span><span style=”font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, sans-serif; orphans: 2; widows: 2;”>glucocorticoid receptor agonist. The&nbsp;</span><span style=”font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;”>Phase-I/II clinical trials in Back pain in Australia (Epidural) (NCT03952377) started in 2019.</span></span></span>

IC50 58 nM (HECM-induced eosinophil survival)
IUPAC Name [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
InChI InChI=1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1
InChIKey AKUJBENLRBOFTD-RPRRAYFGSA-N
SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)O)F)C
Reference

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[1]. Kao-Shan CS, et al. Cytogenetic effects of amsacrine on human lymphocytes in vivo and in vitro. Cancer Treat Rep. 1984 Jul-Aug;68(7-8):989-97.<br />
[2]. Leskiewicz M, Jantas D, Regulska M, Antidepressants attenuate the dexamethasone-induced decrease in viability and proliferation of human neuroblastoma SH-SY5Y cells: A involvement of extracellular regulated kinase (ERK1/2). Neurochem Int. 2013 Jul 29. pii: S0197-0186(13)00202-7.<br />
[3]. Heberden C, Meffray E, Goustard-Langelier B, Dexamethasone inhibits the maturation of newly formed neurons and glia supplemented with polyunsaturated fatty acids. J Steroid Biochem Mol Biol. 2013 Jul 29. pii: S0960-0760(13)00139-8.<br />
[4]. Lu XX, McCoy KS, Hu WK, Dexamethasone reduces IL-17 and Tim-3 expression in BALF of asthmatic mice. J Huazhong Univ Sci Technolog Med Sci. 2013 Aug;33(4):479-84.<br />
[5]. Wyns H, Meyer E, Watteyn A, Pharmacokinetics of dexamethasone after intravenous and intramuscular administration in pigs. Vet J. 2013 Jul 19. pii: S1090-0233(13)00299-2.</p>

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