Dexamethasone-d3-1

• CAT Number: I041008
• Molecular Formula: C22H26D3FO5
• Molecular Weight: 395.48
• Purity: ≥95%
• Synonyms: (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-16-(trideuteriomethyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• InChI: InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1/i1D3
• InChIKey: UREBDLICKHMUKA-UXFWPANFSA-N
• SMILES: [2H]C([2H])([2H])[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C

Dexamethasone-d3-1(CAT: I041008) is a deuterated form of dexamethasone, a potent synthetic glucocorticoid used to reduce inflammation and modulate immune responses. The incorporation of deuterium (D3) in place of hydrogen allows for more precise tracking and quantification in pharmacokinetic studies, particularly when evaluating the metabolism and distribution of the drug. Dexamethasone-d3-1 retains the pharmacological activity of the parent compound, including the suppression of pro-inflammatory cytokine production and the inhibition of immune cell activation. This isotope-labeled version is ideal for studies investigating the pharmacodynamics, metabolism, and long-term effects of glucocorticoid therapy in autoimmune diseases, inflammatory conditions, and transplant medicine.