Dexamethasone-d3

• CAT Number: R036373
• CAS Number: NA
• Molecular Formula: C₂₂H₂₆D₃FO₅
• Molecular Weight: 395.48
• Purity: ≥95%
• Storage: Desiccate at -20C
• IUPAC Name: (8S,9R,10S,11S,13S,14S,16R,17R)-11,17-dideuteriooxy-17-(2-deuteriooxyacetyl)-9-fluoro-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• InChI: UREBDLICKHMUKA-VQPNKHIKSA-N
• InChIKey: InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1/i24D,26D,28D
• SMILES: [2H]OCC(=O)[C@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O[2H])C)C)O[2H]

Dexamethasone-d3 is a deuterated form of dexamethasone, featuring three deuterium atoms incorporated into its molecular structure. This high-purity isotopically labeled compound is essential for advanced research in pharmacology, endocrinology, and drug metabolism. Dexamethasone-d3 is particularly valuable for studying the metabolic pathways, pharmacokinetics, and therapeutic effects of dexamethasone, a potent corticosteroid used to treat a variety of inflammatory and autoimmune conditions, as well as certain cancers. The deuterium labeling allows for precise tracking and quantification in biological systems using mass spectrometry, enhancing the accuracy of studies related to drug absorption, distribution, metabolism, and excretion. This compound is a critical tool for researchers focused on optimizing corticosteroid therapies, understanding drug interactions, and exploring the pharmacodynamics of dexamethasone in various clinical contexts, providing reliable and consistent results in diverse experimental settings.