For research use only. Not for therapeutic Use.
Dexmecamylamine, also known as TC-5214 and NIH-11008, is a nicotinic channel modulator with antidepressant activity. TC-5214 demonstrated positive effects in a number of animal models of depression and anxiety. TC-5214 was active in the forced swim test in rats (minimum effective dose (MED)=3 mg/kg i.p.), a classical depression model. It was also active in the behavioral despair test in mice (0.1-3.0 mg/kg i.p.), another model of depression.
| Catalog Number | I006447 |
| CAS Number | 107596-30-5 (HCl) |
| Synonyms | TC-5214; TC 5214; TC5214; NIH-11008; NIH 11008; NIH11008; Dexmecamylamine; Dexmecamylamine HCl;(1R,2S,4S)-N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride |
| Molecular Formula | C11H22ClN |
| Purity | ≥95% |
| Target | nicotinic channel modulator |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | (1S,3S,4R)-N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine;hydrochloride |
| InChI | InChI=1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11-;/m0./s1 |
| InChIKey | PKVZBNCYEICAQP-GSTSRXQZSA-N |
| SMILES | CC1(C2CCC(C2)C1(C)NC)C.Cl |
| Reference | </br> 1:Zhao HP, Xiang BR. Discontinued cardiovascular drugs in 2013 and 2014. Expert Opin Investig Drugs. 2015;24(8):1083-92. doi: 10.1517/13543784.2015.1051619. PubMed PMID: 26162717. |
