Dexrazoxane hydrochloride

• CAT Number: I010833
• CAS Number: 1263283-43-7
• Molecular Formula: C11H17ClN4O4
• Molecular Weight: 304.731
• Purity: ≥95%
• Synonyms: Alternative Name: ICRF-187
• Solubility: Soluble to 100 mM in water and to 100 mM in DMSO
• Storage: Desiccate at RT
• IUPAC Name: 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione;hydrochloride
• InChI: InChI=1S/C11H16N4O4.ClH/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14;/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19);1H/t7-;/m0./s1
• InChIKey: BIFMNMPSIYHKDN-FJXQXJEOSA-N
• SMILES: CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.Cl

Dexrazoxane hydrochloride (CAT: I010833) is a multifunctional compound with significant pharmacological implications. Acting as a topoisomerase II inhibitor and intracellular ion chelator, it forms a bridge and stabilizes an interface between two ATPase promoters, effectively inhibiting topoisomerase II activity. Notably, its co-administration with doxorubicin exhibits cardioprotective properties by reducing the formation of reactive oxygen species (ROS) and activating the PI3K/Akt survival pathway.