For research use only. Not for therapeutic Use.
DFHBI-2T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=500 nm/523 nm). DFHBI-2T is used to image RNA in live cells[1][2].
Spinach2 imaged DFHBI-2T results in fluorescence that is detectable using the yellow emission channel[2].
| Catalog Number | I045634 |
| CAS Number | 1539318-40-5 |
| Synonyms | (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-3-methyl-2-(trifluoromethyl)imidazol-4-one |
| Molecular Formula | C12H7F5N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H7F5N2O2/c1-19-10(21)8(18-11(19)12(15,16)17)4-5-2-6(13)9(20)7(14)3-5/h2-4,20H,1H3/b8-4- |
| InChIKey | CGFZNPPTJGGWPN-YWEYNIOJSA-N |
| SMILES | CN1C(=O)C(=CC2=CC(=C(C(=C2)F)O)F)N=C1C(F)(F)F |
| Reference | [1]. Wenjiao Song, et al. Plug-and-play fluorophores extend the spectral properties of Spinach. J Am Chem Soc. 2014 Jan 29;136(4):1198-201. [2]. Robert J Trachman 3rd, et al. Structural Principles of Fluorescent RNA Aptamers. Trends Pharmacol Sci. 2017 Oct;38(10):928-939. |
