For research use only. Not for therapeutic Use.
DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of ∼0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9[1].
DFP00173 inhibits the glycerol permeability of human erythrocytes with an IC50 of ~0.2 µM[1].
| Catalog Number | I017620 |
| CAS Number | 672286-03-2 |
| Synonyms | 1-(2,6-dichlorophenyl)-3-(5-nitrothiophen-3-yl)urea |
| Molecular Formula | C11H7Cl2N3O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C11H7Cl2N3O3S/c12-7-2-1-3-8(13)10(7)15-11(17)14-6-4-9(16(18)19)20-5-6/h1-5H,(H2,14,15,17) |
| InChIKey | AATXXTHMITUAOJ-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C(=C1)Cl)NC(=O)NC2=CSC(=C2)[N+](=O)[O-])Cl |
| Reference | [1]. Sonntag Y, et al. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019 May 3;294(18):7377-7387. |
