DFPM

• CAT Number: R066658
• CAS Number: 301338-95-4
• Molecular Formula: C16H15Cl2NOS
• Molecular Weight: 340.262
• Purity: ≥95%
• Synonyms: [5-(3,4-dichlorophenyl)-2-furanyl]-1-piperidinyl-methanethione
• Storage: -20°C
• IUPAC Name: [5-(3,4-dichlorophenyl)furan-2-yl]-piperidin-1-ylmethanethione
• InChI: InChI=1S/C16H15Cl2NOS/c17-12-5-4-11(10-13(12)18)14-6-7-15(20-14)16(21)19-8-2-1-3-9-19/h4-7,10H,1-3,8-9H2
• InChIKey: SFXIAQRTVLSMEJ-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)C(=S)C2=CC=C(O2)C3=CC(=C(C=C3)Cl)Cl

DFPM (CAS 301338-95-4) is a modulator of plant signaling first demonstrated to down-regulate ABA-dependent gene expression (IC50 = 3 µM) and stomatal closure. It stimulates the expression of several plant defense-related genes and blocks signaling triggered by phytoalexin deficient 4 (PAD4). DFPM also induces root growth arrest in certain accessions of A. thaliana through the expression of a novel protein that interacts with PAD4.

Reference

1.Kim, T.-H.,Hauser, F.,Ha, T., et al. Chemical genetics reveals negative regulation of abscisic acid signaling by a plant immune response pathway. Curr. Biol. 21(11), 990-997 (2011).
2.Kim, T.-<wbr style="box-sizing: border-box;" />H., Kunz, H.-<wbr style="box-sizing: border-box;" />H., Bhattacharjee, S., et al. Natural variation in small molecule-<wbr style="box-sizing: border-box;" />induced TIR-<wbr style="box-sizing: border-box;" />NB-<wbr style="box-sizing: border-box;" />LRR signaling induces root growth arrest via EDS1-<wbr style="box-sizing: border-box;" /> and PAD4-<wbr style="box-sizing: border-box;" />complexed R protein VICTR in Arabidopsis. Plant Cell 24(12), 5177-5192 (2012).