DFPQ

• CAT Number: I047721
• CAS Number: 911678-60-9
• Molecular Formula: C20H20F2N4
• Molecular Weight: 354.4
• Purity: ≥95%

DFPQ is a potent and selective β-arrestin-biased negative allosteric modulator (NAM) for the β2-adrenergic receptor. DFPQ selectively inhibits β-arrestin interaction with the β2AR without affecting β-agonist-promoted cAMP production. DFPQ attenuates functional desensitization of the β2AR in airway smooth muscle, augmenting the ability of β-agonists to sustain bronchorelaxation and inhibition of cell migration under conditions of chronic β-agonist treatment.
KEYWORDS: DFPQ | Supplier | β2 NAM | AP-06-202 | AP 06-202 | AP06-202 | CAS [911678-60-9] | (Nor-)Adrenaline | Adrenoceptor β2 | NAM | Receptors | Asthma | Airway disease

Reference

M Ippolito et al. Identification of a β-arrestin-biased negative allosteric modulator for the β2-adrenergic receptor. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2302668120.