DG026

• CAT Number: I006470
• CAS Number: 2035046-17-2
• Molecular Formula: C35H40N3O4P
• Molecular Weight: 597.70
• Purity: ≥95%
• Synonyms: DG026; DG-026; DG 026.;(2-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-4,4-diphenylbutyl)((R)-1-amino-3-phenylpropyl)phosphinic acid
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: [(2R)-2-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]-4,4-diphenylbutyl]-[(1R)-1-amino-3-phenylpropyl]phosphinic acid
• InChI: InChI=1S/C35H40N3O4P/c36-33(22-21-26-13-5-1-6-14-26)43(41,42)25-30(35(40)38-32(34(37)39)23-27-15-7-2-8-16-27)24-31(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30-33H,21-25,36H2,(H2,37,39)(H,38,40)(H,41,42)/t30?,32-,33+/m0/s1
• InChIKey: FDAGDZVCWKCEEX-ITBZIINNSA-N
• SMILES: C1=CC=C(C=C1)CC[C@H](N)P(=O)(C[C@H](CC(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N)O

DG026(CAT: I006470) is a potent and selective inhibitor of insulin-regulated aminopeptidase (IRAP), widely used in neuropharmacological and metabolic research. By targeting IRAP, DG026 modulates the processing and release of peptides involved in cognitive function, memory, and glucose metabolism. This compound is particularly valuable for studying the role of IRAP in neurodegenerative diseases, such as Alzheimer’s disease, and metabolic disorders, including diabetes. With high specificity and stability, DG026 is suitable for in vitro and in vivo studies, supporting the exploration of IRAP-related mechanisms and the development of novel therapeutic strategies.