DHODH-IN-11

• CAT Number: I016854
• CAS Number: 1263303-95-2
• Molecular Formula: C₁₅H₁₁N₃O₂
• Molecular Weight: 265.27
• Purity: ≥95%
• Target: Cell Cycle/DNA Damage
• Storage: -20°C
• IUPAC Name: (2E)-2-cyano-2-hydroxyimino-N-(4-phenylphenyl)acetamide
• InChI: InChI=1S/C15H11N3O2/c16-10-14(18-20)15(19)17-13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-9,20H,(H,17,19)/b18-14+
• InChIKey: YFGFEIDPJVPFOM-NBVRZTHBSA-N
• SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)NC(=O)/C(=N/O)/C#N

DHODH-IN-11（Cat No.:I016854）is a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH), an enzyme critical for the de novo pyrimidine biosynthesis pathway. By inhibiting DHODH, this compound disrupts nucleotide synthesis, effectively reducing the proliferation of rapidly dividing cells, such as cancer cells and activated immune cells. DHODH-IN-11 has been explored for its potential in cancer therapy, autoimmune diseases, and viral infections due to its ability to target cell proliferation. Its selective mechanism offers a promising approach for the development of new therapeutic agents in oncology and immunology.

Reference

[1]. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.