For research use only. Not for therapeutic Use.
DHODH-IN-16 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH[1].
DHODH-IN-16 (Example 22) potently inhibits the growth of MOLM-13 cells with an IC50 of 0.2 nM[1].
| Catalog Number | I044437 |
| CAS Number | 2511248-11-4 |
| Synonyms | 6-[4-ethyl-3-(hydroxymethyl)-5-oxo-1,2,4-triazol-1-yl]-7-fluoro-2-(2-methylphenyl)-4-propan-2-ylisoquinolin-1-one |
| Molecular Formula | C24H25FN4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H25FN4O3/c1-5-27-22(13-30)26-29(24(27)32)21-11-16-17(10-19(21)25)23(31)28(12-18(16)14(2)3)20-9-7-6-8-15(20)4/h6-12,14,30H,5,13H2,1-4H3 |
| InChIKey | BZKHQYHQHLKJNX-UHFFFAOYSA-N |
| SMILES | CCN1C(=NN(C1=O)C2=C(C=C3C(=C2)C(=CN(C3=O)C4=CC=CC=C4C)C(C)C)F)CO |
| Reference | [1]. Scott Kuduk, et al. Dihydroorotate dehydrogenase inhibitors. WO2020212897A1. |
