DHODH-IN-23

• CAT Number: I041700
• CAS Number: 1346705-53-0
• Molecular Formula: C24H21ClFNO4
• Molecular Weight: 441.88
• Purity: ≥95%

DHODH-IN-23 (Compound A) is an orally active DHODH inhibitor that can be used for the research of cancer[1].
DHODH-IN-23 (Compound A; 72 h) inhibits acute myeloid leukemia cells proliferation[1].
DHODH-IN-23 (0.1-3 μM; 72 h) induces CDllb expression in THP-1 cells[1].
DHODH-IN-23 (Compound A; 30 mg/kg; oral; twice daily for 21 days) shows antitumor activity in MV411 mouse xenograft model[1].

Reference

[1]. Srikant Viswanadha, et al. Compositions comprising a dhodh inhibitor for the treatment of acute myeloid leukemia. Patent WO2021079273A1.