For research use only. Not for therapeutic Use.
DHPS-IN-1, with the best DHPS inhibitory potency (IC50 = 0.014 μM), exhibits excellent inhibition against melanoma cells.
| Catalog Number | I045571 |
| CAS Number | 2643300-54-1 |
| Synonyms | 2-(4-bromophenyl)-6-chloro-5-(2-methoxyphenoxy)pyrimidin-4-amine |
| Molecular Formula | C17H13BrClN3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H13BrClN3O2/c1-23-12-4-2-3-5-13(12)24-14-15(19)21-17(22-16(14)20)10-6-8-11(18)9-7-10/h2-9H,1H3,(H2,20,21,22) |
| InChIKey | GBTXLCFBIYCONW-UHFFFAOYSA-N |
| SMILES | COC1=CC=CC=C1OC2=C(N=C(N=C2Cl)C3=CC=C(C=C3)Br)N |
| Reference | [1]. Liu KL, et al. Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation. J Med Chem. 2021 Sep 23;64(18):13356-13372. |
