DHPS-IN-1

• CAT Number: I045571
• CAS Number: 2643300-54-1
• Molecular Formula: C17H13BrClN3O2
• Molecular Weight: 406.66
• Purity: ≥95%
• Synonyms: 2-(4-bromophenyl)-6-chloro-5-(2-methoxyphenoxy)pyrimidin-4-amine
• InChI: InChI=1S/C17H13BrClN3O2/c1-23-12-4-2-3-5-13(12)24-14-15(19)21-17(22-16(14)20)10-6-8-11(18)9-7-10/h2-9H,1H3,(H2,20,21,22)
• InChIKey: GBTXLCFBIYCONW-UHFFFAOYSA-N
• SMILES: COC1=CC=CC=C1OC2=C(N=C(N=C2Cl)C3=CC=C(C=C3)Br)N

DHPS-IN-1, with the best DHPS inhibitory potency (IC50 = 0.014 μM), exhibits excellent inhibition against melanoma cells.

Reference

[1]. Liu KL, et al. Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation. J Med Chem. 2021 Sep 23;64(18):13356-13372.
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