DHQZ 36

• CAT Number: I017158
• CAS Number: 1542098-94-1
• Molecular Formula: C21H18F2N2OS
• Molecular Weight: 384.44
• Purity: ≥95%
• IUPAC Name: 2-(5-ethylthiophen-2-yl)-6-fluoro-3-[(4-fluorophenyl)methyl]-1,2-dihydroquinazolin-4-one
• InChI: InChI=1S/C21H18F2N2OS/c1-2-16-8-10-19(27-16)20-24-18-9-7-15(23)11-17(18)21(26)25(20)12-13-3-5-14(22)6-4-13/h3-11,20,24H,2,12H2,1H3
• SMILES: CCC1=CC=C(S1)C2NC3=C(C=C(C=C3)F)C(=O)N2CC4=CC=C(C=C4)F

DHQZ 36 is a potent inhibitor of retrograde trafficking (IC50 values of 8.1 and 24 μM against JCPyV and HPV16 infectivity, respectively). Protects cells from infections by human polyoma- and papillomaviruses.
KEYWORDS: DHQZ 36 | supplier | Antiviral agent | DHQZ36 | DHQZ-36 | CAS [1542098-94-1] | Retrograde trafficking | Polyomavirus | Papillomavirus | Inhibitor | Dihydroquinazolinone

Reference

DW Carney et al. Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses. Bioorg Med Chem. 2014 Sep 1;22(17):4836-47.