For research use only. Not for therapeutic Use.
DHX9-IN-1 (example 160) is an inhibitor of ATP-dependent RNA helicase A (DHX9), with the IC50 of 9.45 nM that has antitumor activity[1].
| Catalog Number | I040543 |
| CAS Number | 2973747-89-4 |
| Synonyms | 5-[5-(3,3-difluoroazetidin-1-yl)pyridin-2-yl]-N-[3-(methanesulfonamido)phenyl]-1-methylpyrrole-3-carboxamide |
| Molecular Formula | C21H21F2N5O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C21H21F2N5O3S/c1-27-11-14(20(29)25-15-4-3-5-16(9-15)26-32(2,30)31)8-19(27)18-7-6-17(10-24-18)28-12-21(22,23)13-28/h3-11,26H,12-13H2,1-2H3,(H,25,29) |
| InChIKey | NFDWKTIXFFIEAC-UHFFFAOYSA-N |
| SMILES | CN1C=C(C=C1C2=NC=C(C=C2)N3CC(C3)(F)F)C(=O)NC4=CC(=CC=C4)NS(=O)(=O)C |
| Reference | [1]. DANIELS Matthew, H, et al. Preparation of N-sulfonamidophenyl carboxamides as inhibitors of RNA helicase DHX9 and uses thereof. World Intellectual Property Organization, WO2023158795 A1 2023-08-24 |
