DHX9-IN-2

• CAT Number: I040542
• CAS Number: 2973395-71-8
• Molecular Formula: C18H16ClN3O3S2
• Molecular Weight: 421.92
• Purity: ≥95%
• Synonyms: N-[3-chloro-5-(methanesulfonamido)phenyl]-4-(3-methylpyridin-2-yl)thiophene-2-carboxamide
• InChI: InChI=1S/C18H16ClN3O3S2/c1-11-4-3-5-20-17(11)12-6-16(26-10-12)18(23)21-14-7-13(19)8-15(9-14)22-27(2,24)25/h3-10,22H,1-2H3,(H,21,23)
• InChIKey: VDGNPEFFHQRGOP-UHFFFAOYSA-N
• SMILES: CC1=C(N=CC=C1)C2=CSC(=C2)C(=O)NC3=CC(=CC(=C3)Cl)NS(=O)(=O)C

DHX9-IN-2 (example 31) is an inhibitor of ATP-dependent RNA helicase A (DHX9), with the IC50 of 0.0698 nM that has antitumor activity[1].

Reference

[1]. DANIELS Matthew H., et al. Preparation of imidazopyridines, thienopyrimidines, pyrrolopyrimidines and related heterocycles as inhibitors of RNA helicase DHX9 useful in treatment of cancers. World Intellectual Property Organization, WO2023154519 A1 2023-08-17