Di(N-succinimidyl)adipate

• CAT Number: I016651
• CAS Number: 59156-70-6
• Molecular Formula: C₁₄H₁₆N₂O₈
• Molecular Weight: 340.29
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: bis(2,5-dioxopyrrolidin-1-yl) hexanedioate
• InChI: InChI=1S/C14H16N2O8/c17-9-5-6-10(18)15(9)23-13(21)3-1-2-4-14(22)24-16-11(19)7-8-12(16)20/h1-8H2
• InChIKey: LZZXZDMVRZJZST-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCCCC(=O)ON2C(=O)CCC2=O

Di(N-succinimidyl)adipate（Cat No.:I016651） is an alkyl chain-based PROTAC linker commonly employed in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This linker consists of two N-succinimidyl ester groups connected by an adipic acid backbone. It serves as a bridge between the target protein-binding ligand and the E3 ubiquitin ligase-recruiting ligand. The linker provides the necessary flexibility and distance to facilitate the proximity-induced protein degradation mechanism of PROTACs, allowing for selective and targeted degradation of disease-causing proteins within cells.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562