Di-O-methyldemethoxycurcumin

• CAT Number: I017280
• CAS Number: 824951-60-2
• Molecular Formula: C22H22O5
• Molecular Weight: 366.41
• Purity: ≥95%
• Synonyms: (1E,6E)-1-(3,4-dimethoxyphenyl)-7-(4-methoxyphenyl)hepta-1,6-diene-3,5-dione
• InChI: InChI=1S/C22H22O5/c1-25-20-11-6-16(7-12-20)4-9-18(23)15-19(24)10-5-17-8-13-21(26-2)22(14-17)27-3/h4-14H,15H2,1-3H3/b9-4+,10-5+
• InChIKey: FTMVHEMEBLBNPN-LUZURFALSA-N
• SMILES: COC1=CC=C(C=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)OC)OC

Di-O-methyldemethoxycurcumin, a curcuminoid analog, inhibits IL-6 production with an EC50 of 16.20 μg/mL. Anti-inflammatory and antioxidant properties[1].

Reference

[1]. Nuntana Aroonrerk, et al. Inhibitory effects of di-O-demethylcurcumin on interleukin-1β-induced interleukin-6 production from human gingival fibroblasts. J Dent Sci. 2012 Dec;7(14): 350-358.