For research use only. Not for therapeutic Use.
Diacerein is a diacetyl precursor of rhein, an anthraquinone found in plants. Rhein, at 10 µM, inhibits IL-<wbr></wbr>1β signaling, suppressing signaling through NF-<wbr></wbr>κB and AP-<wbr></wbr>1, and reduces the expression of the matrix metalloproteases MMP-<wbr></wbr>1 and MMP-<wbr></wbr>13. Diacerein, presumably after conversion to rhein, down-<wbr></wbr>regulates the expression of the IL-<wbr></wbr>1β receptor on articular chondrocytes, enhances the expression of TGF-<wbr></wbr>β, and increases collagen and aggrecan. It does not alter COX activity. It is mildly effective in ameliorating osteoarthritis.
| Catalog Number | A000159 |
| CAS Number | 13739-02-1 |
| Synonyms | NA |
| Molecular Formula | C19H12O8 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| InChIKey | TYNLGDBUJLVSMA-UHFFFAOYSA-N |
