Diallyl disulfide

• CAT Number: R040441
• CAS Number: 2179-57-9
• Molecular Formula: C6H10S2
• Molecular Weight: 146.27
• Purity: ≥95%
• Synonyms: 3-(prop-2-enyldisulfanyl)prop-1-ene
• InChI: InChI=1S/C6H10S2/c1-3-5-7-8-6-4-2/h3-4H,1-2,5-6H2
• InChIKey: PFRGXCVKLLPLIP-UHFFFAOYSA-N
• SMILES: C=CCSSCC=C

Diallyl disulfide, an active compound in garlic oil, is an orally active human squalene monooxygenase inhibitor with an IC50 of 400 μM for squalene epoxidation. Diallyl disulfide exhibits obvious anti-inflammatory, anti-oxidative, antidepressant and anti-tumor activities[1][2][3][4].
Diallyl disulfide (30, 60, 120, 240 μM; 12, 24, 48 h) suppresses HT-29 cell growth[2].
Diallyl disulfide (30, 60, 120 μM; 24 h) induces cell cycle arrest in the G2/M-phase in HT-29 cells in a concentration-independent manner[2].
Diallyl disulfide (120 μM) induces the mRNA levels of ARPC3, SPINT2, SOD1, p21 and TACSTD2[2].
Diallyl disulfide (40, 80 mg/kg; IP; pre-treatment 1 h) has a prophylactic effect in LPS-induced depression-like behaviors in mice[3].
Diallyl disulfide (30, 60, 90 mg/kg; oral gavage; three times/week for the last 30 days) dose-dependently reduces cigarette smoke (CS) -induced leukocyte infiltration into the airways and improves lung histology in C57BL/6 mice were exposed to CS for 60 consecutive days[4].

Reference

[1]. Gupta N, et al. Garlic and garlic-derived compounds inhibit human squalene monooxygenase. J Nutr. 2001;131(6):1662-1667.
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[2]. You-Sheng Huang, et al. Diallyl disulfide inhibits the proliferation of HT-29 human colon cancer cells by inducing differentially expressed genes. Mol Med Rep. 2011 May-Jun;4(3):553-9.
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[3]. Xiaoyou Wei, et al. Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress. Inflammation. 2021 Aug;44(4):1381-1395.
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[4]. Aline de Oliveira Pontes Cardoso, et al. Diallyl disulfide prevents cigarette smoke-induced emphysema in mice. Pulm Pharmacol Ther. 2021 Aug:69:102053.
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