For research use only. Not for therapeutic Use.
DiaPep277 is a 24 amino acid peptide derived from positions 437-460 in HSP60. DiaPep277 arrests the progression of β-cell destruction in NOD mice. DiaPep277 has an immune modulatory effect on diabetogenic T cells in animal models of diabetes[1][2].
DiaPep277 (50 μg; i.p.; single dosage) causes strong splenic T cells responses, and strong diabetogenic clones 27, C7, and C9 responses[2].
| Catalog Number | I042684 |
| CAS Number | 179822-83-4 |
| Molecular Formula | C106H180N28O34 |
| Purity | ≥95% |
| Reference | [1]. Eldor R, et al. Immune modulation in type 1 diabetes mellitus using DiaPep277: a short review and update of recent clinical trial results. Diabetes Metab Res Rev. 2009 May;25(4):316-20. [2]. Elias D, et al. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3088-91. |
