Dibromomaleimide-C5-COOH

• CAT Number: I040167
• CAS Number: 1443214-97-8
• Molecular Formula: C10H11Br2NO4
• Molecular Weight: 369.01
• Purity: ≥95%
• Synonyms: 6-(3,4-dibromo-2,5-dioxopyrrol-1-yl)hexanoic acid
• InChI: InChI=1S/C10H11Br2NO4/c11-7-8(12)10(17)13(9(7)16)5-3-1-2-4-6(14)15/h1-5H2,(H,14,15)
• InChIKey: XABAXSUMIXSPEP-UHFFFAOYSA-N
• SMILES: C(CCC(=O)O)CCN1C(=O)C(=C(C1=O)Br)Br

Dibromomaleimide-C5-COOH (Cat No.: I040167) is a chemical compound used in bioconjugation and molecular labeling. It features a dibromomaleimide group, which is reactive and can form covalent bonds with thiol groups on proteins, peptides, or other biomolecules, making it useful for protein modification and crosslinking applications. The C5-COOH (carboxyl) group enhances solubility and provides a functional handle for further conjugation or labeling. This compound is used in drug delivery, diagnostic applications, and the study of protein-protein interactions in various research contexts.

Reference

[1]. Behrens CR, et al. Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs. Mol Pharm. 2015 Nov 2;12(11):3986-98.
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