Dichloroimipramine Hydrochloride

• CAT Number: R040143
• CAS Number: 115189-28-1
• Molecular Formula: C19H23Cl3N2
• Molecular Weight: 385.757
• Purity: ≥95%
• Synonyms: 3,7-Dichloro-5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine Hydrochloride; 3,7-Dichloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine Hydrochloride
• Storage: -20°C
• IUPAC Name: 3-(2,9-dichloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride
• InChI: InChI=1S/C19H22Cl2N2.ClH/c1-22(2)10-3-11-23-18-12-16(20)8-6-14(18)4-5-15-7-9-17(21)13-19(15)23;/h6-9,12-13H,3-5,10-11H2,1-2H3;1H
• InChIKey: ZQIGPUHBKAQZPE-UHFFFAOYSA-N
• SMILES: CN(C)CCCN1C2=C(CCC3=C1C=C(C=C3)Cl)C=CC(=C2)Cl.Cl

Dichloroimipramine Hydrochloride (CAS 115189-28-1) is the analog of Imipramine Hydrochloride, a tricyclic antidepressant.

Reference

1.Wood, M. D. "Examination of the relationship between the uptake site for 5-hydroxytryptamine and the high affinity binding site for [3H] imipramine II: The role of sodium ions." Neuropharmacology 26.8 (1987): 1081-1085.
2.Casis, Oscar, and José A. Sánchez-Chapula. "Disopyramide, imipramine, and amitriptyline bind to a common site on the transient outward K+ channel." Journal of cardiovascular pharmacology 32.4 (1998): 521-526.
3.Linnér, Love, et al. "Locus coeruleus neuronal activity and noradrenaline availability in the frontal cortex of rats chronically treated with imipramine: effect of α2-adrenoceptor blockade." Biological psychiatry 46.6 (1999): 766-774.