Diclofenac acyl glucuronide

• CAT Number: R006077
• CAS Number: 64118-81-6
• Molecular Formula: C20H19Cl2NO8
• Molecular Weight: 472.27
• Purity: ≥95%
• Synonyms: (2S,3S,4S,5R,6S)-6-[2-[2-(2,6-dichloroanilino)phenyl]acetyl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
• InChI: InChI=1S/C20H19Cl2NO8/c21-10-5-3-6-11(22)14(10)23-12-7-2-1-4-9(12)8-13(24)30-20-17(27)15(25)16(26)18(31-20)19(28)29/h1-7,15-18,20,23,25-27H,8H2,(H,28,29)/t15-,16-,17+,18-,20+/m0/s1
• InChIKey: JXIKYYSIYCILNG-HBWRTXEVSA-N
• SMILES: C1=CC=C(C(=C1)CC(=O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C(=O)O)O)O)O)NC3=C(C=CC=C3Cl)Cl

Diclofenac acyl glucuronide（Cat No.:R006077）is a metabolite of diclofenac, a commonly used nonsteroidal anti-inflammatory drug (NSAID). It is formed in the liver through glucuronidation, a process where the glucuronic acid molecule is added to diclofenac, enhancing its solubility and excretion. This metabolite is pharmacologically active and may contribute to the therapeutic effects of diclofenac, but it is also associated with some of the drug’s adverse effects, particularly hepatotoxicity. Studies on diclofenac acyl glucuronide help researchers understand its role in diclofenac’s pharmacokinetics, safety profile, and potential side effects.