Didanosine

• CAT Number: A001017
• CAS Number: 69655-05-6
• Molecular Formula: C10H12N4O3
• Molecular Weight: 236.23
• Purity: ≥95%
• Synonyms: 2/’,3/’-Dideoxyinosine; 69655-05-6; DIDEOXYINOSINE; Videx; Videx EC
• Target: HIV
• Solubility: >10.3mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
• InChI: InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1
• InChIKey: BXZVVICBKDXVGW-NKWVEPMBSA-N
• SMILES: C1C[C@@H](O[C@@H]1CO)N2C=NC3=C2N=CNC3=O

Didanosine（Cat No.:A001017）, or ddI, is a nucleoside reverse transcriptase inhibitor (NRTI) widely utilized in HIV research. As an analog of deoxyadenosine, it inhibits viral replication by interfering with reverse transcriptase, causing premature DNA chain termination. Didanosine has played a pivotal role in understanding HIV treatment strategies, resistance mechanisms, and the optimization of antiretroviral therapies. Its application extends to investigating combination therapy efficacy and viral mutational responses. With its well-documented pharmacological properties, Didanosine remains an essential compound in virology research, aiding in the advancement of treatments for retroviral infections.

Reference

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