For research use only. Not for therapeutic Use.
Didesmethylrocaglamide (Cat No.:I015334) is a chemical compound derived from the flavonoid family. It possesses interesting pharmacological properties, including anti-cancer and anti-inflammatory activities. Didesmethylrocaglamide has been found to inhibit the growth of cancer cells by targeting multiple cellular pathways involved in tumor progression. It has shown particular efficacy against various types of cancer, including leukemia, breast cancer, and pancreatic cancer. Additionally, this compound exhibits anti-inflammatory effects by modulating the activity of inflammatory mediators. Didesmethylrocaglamide represents a potential therapeutic candidate for the treatment of cancer and inflammatory diseases, and further research is being conducted to explore its mechanisms of action and clinical applications.
| Catalog Number | I015334 |
| CAS Number | 177262-30-5 |
| Molecular Formula | C₂₇H₂₇NO₇ |
| Purity | ≥95% |
| IUPAC Name | (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide |
| InChI | InChI=1S/C27H27NO7/c1-32-17-11-9-16(10-12-17)27-22(15-7-5-4-6-8-15)21(25(28)30)24(29)26(27,31)23-19(34-3)13-18(33-2)14-20(23)35-27/h4-14,21-22,24,29,31H,1-3H3,(H2,28,30)/t21-,22-,24-,26+,27+/m1/s1 |
| InChIKey | RMNPQEWLGQURNX-PXIJUOARSA-N |
| SMILES | COC1=CC=C(C=C1)[C@]23[C@@H]([C@H]([C@H]([C@]2(C4=C(O3)C=C(C=C4OC)OC)O)O)C(=O)N)C5=CC=CC=C5 |
| Reference | [1]. Long-Sheng Chang, et al. Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas. Mol Cancer Ther. 2020 Mar;19(3):731-741.<br>[2]. Long-Sheng Chang, et al. Abstract 1950: The eIF4A inhibitors didesmethylrocaglamide and rocaglamide as effective treatments for pediatric bone and soft-tissue sarcomas. Cancer Res 2020;80(16 Suppl):Abstract nr 1950. |
