Didox

• CAT Number: I004623
• CAS Number: 69839-83-4
• Molecular Formula: C7H7NO4
• Molecular Weight: 169.1
• Purity: ≥95%
• Synonyms: N-3,4-tridhydroxy-benzamide
• Target: DNA/RNA Synthesis
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChIKey: QJMCKEPOKRERLN-UHFFFAOYSA-N

Didox (CAT: I004623) is a potent inhibitor of ribonucleotide reductase (RR), a crucial enzyme involved in DNA synthesis and repair. By disrupting the production of deoxyribonucleotides, Didox hampers the essential processes of DNA replication and repair. This disruption contributes to its antitumor effects, making it an important compound in cancer research and therapy. Over the years, Didox has demonstrated its ability to impede cancer cell proliferation and survival, thereby showing promise as an agent for combating various types of cancers.

Reference

[1]. Shah KN, et al. Targeting Ribonucleotide Reductase M2 and NF-κB Activation with Didox to Circumvent Tamoxifen Resistance in Breast Cancer. Mol Cancer Ther. 2015 Nov;14(11):2411-2421.

[2]. Abdel-Latif GA, et al. The chemomodulatory effects of resveratrol and Didox on herceptin cytotoxicity in breast cancer cell lines. Sci Rep. 2015 Jul 9;5:12054.

[3]. Bhave S, et al. Ribonucleotide reductase inhibitors hydroxyurea, Didox, and trimidox inhibit human cytomegalovirus replication in vitro and synergize with ganciclovir. Antiviral Res. 2013 Oct;100(1):151-158.