For research use only. Not for therapeutic Use.
DIDS (4,4′-Diisothiocyanostilbene-2,2′-disulfonic acid)(CAT: I026098) is a multifunctional compound used in molecular biology and biochemistry research. It is a potent inhibitor of RAD51, a key protein involved in homologous recombination, and is widely studied for its role in DNA repair and genomic stability. Additionally, DIDS acts as an anion exchange inhibitor, targeting exchangers such as the chloride-bicarbonate exchanger. Initially, it blocks these transporters reversibly, followed by an irreversible inhibition mechanism, making it valuable for studying ion transport and cellular homeostasis. Researchers leverage DIDS to explore therapeutic approaches in cancer, particularly by disrupting RAD51-mediated DNA repair pathways, and to investigate anion exchange mechanisms in physiology and disease.
| CAS Number | 53005-05-3 |
| Synonyms | DIDS; |
| Molecular Formula | C16H10N2O6S4 |
| Purity | 98% |
| Target | Cell Cycle/DNA Damage |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (E)-6,6'-(ethene-1,2-diyl)bis(3-isothiocyanatobenzenesulfonic acid) |
| InChI | InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+ |
| InChIKey | YSCNMFDFYJUPEF-OWOJBTEDSA-N |
| SMILES | O=S(C1=CC(N=C=S)=CC=C1/C=C/C2=CC=C(N=C=S)C=C2S(=O)(O)=O)(O)=O |
