DIDS

For research use only. Not for therapeutic Use.

  • CAT Number: I026098
  • CAS Number: 53005-05-3
  • Molecular Formula: C16H10N2O6S4
  • Molecular Weight: 454.5
  • Purity: 98%
Inquiry Now

DIDS is a RAD51 inhibitor and anion exchange inhibitor. It acts by blocking reversibly, and later irreversibly, exchangers such as chloride-bicarbonate exchanger.


Catalog Number I026098
CAS Number 53005-05-3
Synonyms

DIDS;

Molecular Formula C16H10N2O6S4
Purity 98%
Target Cell Cycle/DNA Damage
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name (E)-6,6'-(ethene-1,2-diyl)bis(3-isothiocyanatobenzenesulfonic acid)
InChI InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+
InChIKey YSCNMFDFYJUPEF-OWOJBTEDSA-N
SMILES O=S(C1=CC(N=C=S)=CC=C1/C=C/C2=CC=C(N=C=S)C=C2S(=O)(O)=O)(O)=O
Reference

1: Zhang Q, Jing H, Su HC. Recent Advances in DOCK8 Immunodeficiency Syndrome. J Clin Immunol. 2016 Jul;36(5):441-9. doi: 10.1007/s10875-016-0296-z. Epub 2016 May 20. Review. PubMed PMID: 27207373; PubMed Central PMCID: PMC4914394.
2: Thinnes FP. Opening up of plasmalemma type-1 VDAC to form apoptotic "find me signal" pathways is essential in early apoptosis – evidence from the pathogenesis of cystic fibrosis resulting from failure of apoptotic cell clearance followed by sterile inflammation. Mol Genet Metab. 2014 Apr;111(4):439-44. doi: 10.1016/j.ymgme.2014.02.001. Epub 2014 Feb 13. Review. PubMed PMID: 24613483.
3: DiNuzzo M, Mangia S, Maraviglia B, Giove F. Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes. Neurochem Int. 2013 Nov;63(5):458-64. doi: 10.1016/j.neuint.2013.08.004. Epub 2013 Aug 19. Review. PubMed PMID: 23968961; PubMed Central PMCID: PMC4082998.
4: Liu Z, Liu L, Zhang Z, Chen Z, Zhao B. Cholesterol-reducing agents for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD008184. doi: 10.1002/14651858.CD008184.pub2. Review. PubMed PMID: 23633351.
5: Romero MF, Chen AP, Parker MD, Boron WF. The SLC4 family of bicarbonate (HCO₃⁻) transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):159-82. doi: 10.1016/j.mam.2012.10.008. Review. PubMed PMID: 23506864; PubMed Central PMCID: PMC3605756.
6: Dahl G, Qiu F, Wang J. The bizarre pharmacology of the ATP release channel pannexin1. Neuropharmacology. 2013 Dec;75:583-93. doi: 10.1016/j.neuropharm.2013.02.019. Epub 2013 Mar 13. Review. PubMed PMID: 23499662; PubMed Central PMCID: PMC3711969.
7: Markovich D. Sodium-sulfate/carboxylate cotransporters (SLC13). Curr Top Membr. 2012;70:239-56. doi: 10.1016/B978-0-12-394316-3.00007-7. Review. PubMed PMID: 23177988.
8: Shennan DB. Placental sulphate transport: a review of functional and molecular studies. Placenta. 2012 Aug;33(8):599-603. doi: 10.1016/j.placenta.2012.04.008. Epub 2012 May 12. Review. PubMed PMID: 22578714.
9: Sanders KM, Zhu MH, Britton F, Koh SD, Ward SM. Anoctamins and gastrointestinal smooth muscle excitability. Exp Physiol. 2012 Feb;97(2):200-6. doi: 10.1113/expphysiol.2011.058248. Epub 2011 Oct 14. Review. PubMed PMID: 22002868; PubMed Central PMCID: PMC3272164.
10: Szentandrássy N, Nagy D, Ruzsnavszky F, Harmati G, Bányász T, Magyar J, Szentmiklósi AJ, Nánási PP. Powerful technique to test selectivity of agents acting on cardiac ion channels: the action potential voltage-clamp. Curr Med Chem. 2011;18(24):3737-56. Review. PubMed PMID: 21774754.
11: Zhang Q, Davis JC, Dove CG, Su HC. Genetic, clinical, and laboratory markers for DOCK8 immunodeficiency syndrome. Dis Markers. 2010;29(3-4):131-9. doi: 10.3233/DMA-2010-0737. Review. PubMed PMID: 21178272; PubMed Central PMCID: PMC3835385.
12: Alper SL. Molecular physiology and genetics of Na+-independent SLC4 anion exchangers. J Exp Biol. 2009 Jun;212(Pt 11):1672-83. doi: 10.1242/jeb.029454. Review. PubMed PMID: 19448077; PubMed Central PMCID: PMC2683012.
13: Onken H, Moffett DF. Revisiting the cellular mechanisms of strong luminal alkalinization in the anterior midgut of larval mosquitoes. J Exp Biol. 2009 Feb;212(Pt 3):373-7. doi: 10.1242/jeb.023580. Review. PubMed PMID: 19151212; PubMed Central PMCID: PMC2706088.
14: Chen B, Nicol G, Cho WK. Role of calcium in volume-activated chloride currents in a mouse cholangiocyte cell line. J Membr Biol. 2007 Jan;215(1):1-13. Epub 2007 May 5. Review. PubMed PMID: 17483866.
15: Jakab M, Schmidt S, Grundbichler M, Paulmichl M, Hermann A, Weiger T, Ritter M. Hypotonicity and ethanol modulate BK channel activity and chloride currents in GH4/C1 pituitary tumour cells. Acta Physiol (Oxf). 2006 May-Jun;187(1-2):51-9. Review. PubMed PMID: 16734742.
16: Alper SL. Molecular physiology of SLC4 anion exchangers. Exp Physiol. 2006 Jan;91(1):153-61. Epub 2005 Oct 20. Review. Erratum in: Exp Physiol. 2006 Mar;91(2):481. PubMed PMID: 16239253.
17: Pusch M, Zifarelli G, Murgia AR, Picollo A, Babini E. Channel or transporter? The CLC saga continues. Exp Physiol. 2006 Jan;91(1):149-52. Epub 2005 Sep 22. Review. PubMed PMID: 16179405.
18: Romero MF, Fulton CM, Boron WF. The SLC4 family of HCO 3 – transporters. Pflugers Arch. 2004 Feb;447(5):495-509. Epub 2004 Jan 14. Review. PubMed PMID: 14722772.
19: Kito Y, Suzuki H. Electrophysiological properties of gastric pacemaker potentials. J Smooth Muscle Res. 2003 Oct;39(5):163-73. Review. PubMed PMID: 14695027.
20: Markovich D, Murer H. The SLC13 gene family of sodium sulphate/carboxylate cotransporters. Pflugers Arch. 2004 Feb;447(5):594-602. Epub 2003 Aug 12. Review. Erratum in: Pflugers Arch. 2004 Feb;447(5):816-7. PubMed PMID: 12915942.

Request a Quote