For research use only. Not for therapeutic Use.
Dienestrol（Cat No.:I005040）, is a synthetic nonsteroidal estrogen that has been used in hormone replacement therapy (HRT) and as an estrogenic medication. It was commonly prescribed to address symptoms associated with menopause, such as hot flashes and vaginal dryness. Dienestrol acts by binding to estrogen receptors in the body, mimicking the effects of natural estrogen.
| Catalog Number | I005040 |
| CAS Number | 84-17-3 |
| Molecular Formula | C18H18O2 |
| Purity | ≥95% |
| Target | Estrogen Receptor/ERR |
| Solubility | 10 mM in DMSO |
| Storage | Room Temperature |
| IUPAC Name | 4-[(2E,4E)-4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol |
| InChI | InChI=1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3/b17-3+,18-4+ |
| InChIKey | NFDFQCUYFHCNBW-SCGPFSFSSA-N |
| SMILES | CC=C(C1=CC=C(C=C1)O)C(=CC)C2=CC=C(C=C2)O |
| Reference | </br>1:Preparation and characterization of magnetic molecularly imprinted polymers for selective trace extraction of dienestrol in seawater. He XP, Lian ZR, Tan LJ, Wang JT.J Chromatogr A. 2016 Oct 21;1469:8-16. doi: 10.1016/j.chroma.2016.09.052. Epub 2016 Sep 23. PMID: 27688174 </br>2:Packed-fiber solid-phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry for determination of diethylstilbestrol, hexestrol, and dienestrol residues in milk products. Hu WY, Kang XJ, Zhang C, Yang J, Ling R, Liu EH, Li P.J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:7-13. doi: 10.1016/j.jchromb.2014.02.036. Epub 2014 Mar 2. PMID: 24636894 </br>3:Preparation of a stir bar sorptive extraction coating based on molecularly imprinted polymer and its application in the extraction of dienestrol and hexestrol in complicated samples. Nong S, Lin F, Huang X, Yuan D.Se Pu. 2012 Nov;30(11):1133-42. PMID: 23451515 </br>4:Trace analysis of diethylstilbestrol, dienestrol and hexestrol in environmental water by Nylon 6 nanofibers mat-based solid-phase extraction coupled with liquid chromatography-mass spectrometry. Xu Q, Wang M, Yu S, Tao Q, Tang M.Analyst. 2011 Dec 7;136(23):5030-7. doi: 10.1039/c1an15494j. Epub 2011 Oct 12. PMID: 21994916 </br>5:Ability of Group IVB metallocene polyethers containing dienestrol to arrest the growth of selected cancer cell lines. Roner MR, Carraher CE Jr, Shahi K, Ashida Y, Barot G.BMC Cancer. 2009 Oct 7;9:358. doi: 10.1186/1471-2407-9-358. PMID: 19811643 Free PMC Article</br>6:Validation of screening method for residues of diethylstilbestrol, dienestrol, hexestrol, and zeranol in bovine urine using immunoaffinity chromatography and gas chromatography/mass spectrometry. Dickson LC, MacNeil JD, Reid J, Fesser AC.J AOAC Int. 2003 Jul-Aug;86(4):631-9. PMID: 14509418 </br>7:Promotive effects of diethylstilbestrol, its metabolite (Z,Z-dienestrol) and a stereoisomer of the metabolite (E,E-dienestrol) in tumorigenesis of rat mammary glands pregnancy-dependently initiated with radiation. Inano H, Suzuki K, Ishii-Ohba H, Yamanouchi H, Takahashi M, Wakabayashi K.Carcinogenesis. 1993 Oct;14(10):2157-63. PMID: 8222069 </br>8:Analysis of diethylstilbestrol, dienestrol and hexestrol in biological samples by immunoaffinity extraction and gas chromatography-negative-ion chemical ionization mass spectrometry. Bagnati R, Castelli MG, Airoldi L, Paleologo Oriundi M, Ubaldi A, Fanelli R.J Chromatogr. 1990 May 18;527(2):267-78. PMID: 2167323 </br>9:Oxidative metabolism of the synthetic estrogens hexestrol and dienestrol indicates reactive intermediates. Metzler M, McLachlan JA.Adv Exp Med Biol. 1981;136 Pt A:829-37. No abstract available. PMID: 6283819 </br>10:Analysis of dienestrol and its dosage forms by high-performance liquid chromatography. Bailey LC, Bailey CA.J Pharm Sci. 1979 Apr;68(4):508-10. PMID: 438981 |
