DIF-3

• CAT Number: M023185
• CAS Number: 113411-17-9
• Molecular Formula: C13H17ClO4
• Molecular Weight: 272.72
• Purity: ≥95%
• Synonyms: 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one
• InChI: InChI=1S/C13H17ClO4/c1-3-4-5-6-8(15)11-9(16)7-10(18-2)12(14)13(11)17/h7,16-17H,3-6H2,1-2H3
• InChIKey: JWBMZIJMSBFBIY-UHFFFAOYSA-N
• SMILES: CCCCCC(=O)C1=C(C(=C(C=C1O)OC)Cl)O

DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression[1].

Reference

[1]. Naoya Kubokura , et al. Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo. J Pharmacol Sci. 2015 Apr;127(4):446-55.
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