Difelikefalin

• CAT Number: I006487
• CAS Number: 1024828-77-0
• Molecular Formula: C36H53N7O6
• Molecular Weight: 679.86
• Purity: 98%
• Synonyms: CR845; CR-845; CR 845; MR-13A-9; MR-13A9; Difelikefalin;1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid
• Target: Neuronal Signaling
• Target Protein: P41145
• Solubility: Soluble in DMSO, not in water
• Appearance: Solid
• Storage: Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
• IUPAC Name: 4-amino-1-[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid
• InChI: InChI=1S/C36H53N7O6/c1-24(2)21-29(32(45)40-28(15-9-10-18-37)34(47)43-19-16-36(39,17-20-43)35(48)49)42-33(46)30(23-26-13-7-4-8-14-26)41-31(44)27(38)22-25-11-5-3-6-12-25/h3-8,11-14,24,27-30H,9-10,15-23,37-39H2,1-2H3,(H,40,45)(H,41,44)(H,42,46)(H,48,49)/t27-,28-,29-,30-/m1/s1
• InChIKey: FWMNVWWHGCHHJJ-SKKKGAJSSA-N
• SMILES: CC(C)C[C@H](C(=O)N[C@H](CCCCN)C(=O)N1CCC(CC1)(C(=O)O)N)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CC=CC=C3)N

Difelikefalin（Cat No.:I006487）is a selective kappa opioid receptor agonist used to treat moderate to severe itching (pruritus) in patients undergoing hemodialysis due to chronic kidney disease. By targeting kappa opioid receptors on peripheral sensory neurons and immune cells, Difelikefalin reduces the sensation of itching without affecting central nervous system opioid receptors, thus minimizing the risk of side effects like sedation or addiction. Administered via intravenous injection during dialysis sessions, Difelikefalin provides a targeted and effective solution for managing pruritus, improving the quality of life for patients suffering from chronic kidney disease-related itching.